芍药甘草汤化学成分、药理作用、临床应用的研究进展及其质量标志物（Q
[关键词]
[摘要]
芍药甘草汤是历代中医常用的经典名方之一，由白芍和炙甘草组成，治疗血虚身痛、脘腹气血不足之疼痛等症。现代临床主要用于治疗颈间腰腿痛证、胃肠道疾病、神经系统疾病、皮肤病等疾病。对近年来芍药甘草汤化学成分、药理作用、临床应用的研究进展进行总结和分析，从质量传递与溯源、成分可测性、成分有效性、成分特有性及复方配伍环境5个方面对芍药甘草汤质量标志物（quality marker，Q-Marker）进行预测。预测分析发现芍药内酯苷、芍药苷、甘草苷、甘草酸、槲皮素、山柰酚、没食子酸可作为芍药甘草汤的Q-Marker，为经典名方芍药甘草汤质量控制体系和全过程质量溯源体系建立提供科学依据。
[Key word]
[Abstract]
Shaoyao Gancao Decoction (芍药甘草汤) is one of the classic prescriptions commonly used in ancient Chinese medicine. It is composed of Baishao (Paeoniae Radix Alba) and Zhigancao (Glycyrrhizae Radix et Rhizoma Praeparata cum Melle) to treat blood deficiency, body pain and pain caused by deficiency of qi and blood in the stomach. In modern clinic, it is mainly used for the treatment of neck and waist pain syndrome, gastrointestinal diseases, nervous system diseases, skin diseases and other diseases. This paper summarized and analyzed the chemical composition, pharmacological effects and clinical application of Shaoyao Gancao Decoction in recent years. Then, its quality marker (Q-Marker) was predicted from five aspects of quality transfer and traceability, component measurability, component effectiveness, component specificity and compound compatibility environment. Finally, it was predicted that albiflorin, paeoniflorin, liquiritin, glycyrrhizic acid, quercetin, kaempferol and gallic acid could be used as Q-Marker of Shaoyao Gancao Decoction. This study provides scientific reference for the establishment of the quality control system and the whole process quality traceability system of the classic Shaoyao Gancao Decoction.
[中图分类号]
R284;R285
[基金项目]
安徽省科技重大专项项目(202203a07020031);安徽省教育厅基金项目(KJ2021ZD0065);大学生创新创业训练计划项目(202110369021)
肖垚垚,朱菁,刘心雨,金骏辉,李雨欢,葛宗瑞,马继浩,张彩云.芍药甘草汤化学成分、药理作用、临床应用的研究进展及其质量标志物（Q-Marker）的预测分析[J].中草药,2022,53(24):7960-7969
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收稿日期: 2022-06-22
在线发布日期: 2022-12-23
出版日期: 2022-12-28
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