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灯盏花素片在健康人体内的药代动力学研究

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2025-05-17 02:39

灯盏花素片在健康人体内的药代动力学研究

Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers

Author:

JIANG Yan

Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China
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ZHANG Wei

Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China
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LIN Xiu-yan

Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China
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LIU Jing

Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China
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XIN Hui

Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China
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CHEN Ying

Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China
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ZHANG Zhuo-bo

Fourth affiliated hospital of Qiqihar Medical College, Qiqihar 150001, China
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摘要:

目的: 建立测定人血浆中灯盏花素浓度的高效液相色谱法。方法: 色谱柱Kromasil C18(4.6 mm×250 mm,5 μm);流动相甲醇-水-冰醋酸(30 ∶70 ∶1)检测波长:335 nm;灯盏乙素作为内标,用HPLC测定人血浆中灯盏花素浓度。结果: 灯盏花素线性范围为0.30~18.0 mg ·L-1,回归方程Y=0.008 7C-0.001 56(r=0.999 6);回收率>80%,日内和日间RSD均<10%。结论: 方法简便、快速、准确,适用于灯盏花素药代动力学研究及血药浓度监测。

Abstract:

Objective: To establish a high performance liquid chromatographic method for determination the concentration of breviscapine in plasma of healthy volunteers. Method: The assay was conducted on the Kromasil C18(250 mm×4.6 mm,5 μm)columnn with methanol-water- glacial acetic acid(30 ∶70 ∶1)as the mobile phase.The detection wave length was set at 335 nm,and scutellarin was taken as the internal standard. Result: The linearity range was 0.30-18.0 mg ·L-1 with a regressive equation of Y=0.008 7 C-0.001 56(r=0.999 6).The recovery was above 80%,with both intra-day RSD and inter-day RSD below 10%. Conclusion: The method was shown to be convenient,rapid,accurate,and suitable for the pharmacokinetic study of breviscapine and monitoring its concentration in clinical application.

引用本文

姜岩,张伟,林秀艳,刘晶,信慧,陈迎,张卓伯.灯盏花素片在健康人体内的药代动力学研究[J].中国实验方剂学杂志,2011,17(13):110~112

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