李花月

花匠小妙招
2024-12-03 19:58

1. Yi Zhao, Hu Chen, Liangguang Yue, Yun Dong, Di Su, Jingyi Lyu, Wenli Li, Huayue Li* Heronamides with unreported skeletons from a deep-sea Streptomyces: discovery and biosynthesis. Org. Chem. Front. 2024, 11, 1175-1183.

2. Huiming Huang, Liangguang Yue, Fayu Deng, Xiaoyu Wang, Ning Wang, Hu Chen, Huayue Li* NMR-metabolomic profiling and genome mining drive the discovery of cyclic decapeptides from a marine Streptomyces. J. Nat. Prod. 2023, 86, 2122-2130

3. Runyi Wang, Yilei Bao, Yujing Dong, Yun Dong, Huayue Li* Genome-directed discovery of antiproliferative bafilomycins from a deepsea-derived Streptomyces samsunensis. Bioorg. Chem. 2023, 138, 106599

4. Yun Dong, Enjing Jin, Runyi Wang, Yilei Bao, Huayue Li* New olimycins from a cold-seep derived Streptomyces olivaceus. Chem. Biodivers., 2023, 20, e202300689

5. Yi Zhao, Hu Chen, Lu Yang, Wenli Li, Huayue Li* Amphonal, a new polyene aldehyde from a deep-sea-derived Streptomyces amphotericinicus. Nat. Prod. Res. 2023, DOI: 10.1080/14786419.202

6. Jing Liu#, Huayue Li*#, Zengzhi Liu, Tong Li, Fei Xiao, Wenli Li* Youssoufenes A2 and A3, antibiotic dimeric cinnamoyl lipids from the ΔdtlA mutant of a marine-derived Streptomyces strain. Mar. Drugs 2022, 20, 394.

7. Yilei Bao#, Huayue Li*#, Yujing Dong, He Duan, Hongcheng Li, and Wenli Li* Genome-Guided Discovery of Antifungal Filipins from a Deep-Sea-Derived Streptomyces antibioticus. J. Nat. Prod. 2022, 25, 365-374

8. Enjing Jin, Huayue Li*, Zengzhi Liu, Fei Xiao, Wenli Li* Antibiotic Dixiamycins from a Cold-Seep Derived Streptomyces olivaceus. J. Nat. Prod. 2021, 84, 2606-2611

9. Huayue Li, Xiao Han, Yujing Dong, Shanshan Xu, Chao Chen, Yingang Feng, Qiu Cui, Wenli Li* Bacillaenes: decomposition trigger point and biofilm enhancement in Bacillus. ACS Omega 2021, 6, 1093-1098

10. Zirong Deng, Jing Liu, Tong Li, Huayue Li, Zengzhi Liu, Yujing Dong, Wenli Li* Unusual type II polyketide synthase system involved in cinnamoyl lipid biosynthesis. Angew. Chem. Int. Ed. 2021, 60, 153-158

11. Huayue Li#, Jing Liu#, Zirong Deng, Tong Li, Zengzhi Liu, Qian Che, Wenli Li* Genetic Manipulation of an aminotransferase family gene dtlA activates youssoufenes in marine-derived Streptomyces youssoufiensis. Org. Lett. 2020, 22, 729-733

12. Lukuan Hou, Zengzhi Liu, Dongqi Yu, Huayue Li*, Jianhua Ju, Wenli Li* Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorg. Chem. 2020, 101, 103954

13. Fei Xiao, Sheng Dong, Yang Liu, Yingang Feng, Huayue Li, Cai-Hong Yun, Qiu Cui, and Wenli Li* Structural basis of specificity for carboxyl-terminated acyl donors in a bacterial acyltransferase. J. Am. Chem. Soc. 2020, 142, 16031-16038

14. Huayue Li, Xiao Han, Jun Zhang, Yujing Dong, Shanshan Xu, Yilei Bao, Chao Chen, Yingang Feng, Qiu Cui, Wenli Li* An effective strategy for identification of highly unstable bacillaenes. J. Nat. Prod. 2019, 82, 3340-3346

15. Jing Hou, Jing Liu, Lu Yang, Zengzhi Liu, Huayue Li*, Qian Che, Tianjiao Zhu, Dehai Li, Wenli Li*, Discovery of an unusual fatty acid amide from the ndgRyo gene mutant of marine-derived Streptomyces youssoufiensis. Mar. Drugs 2019, 17, 12

16. Lu Yang, Lukuan Hou, Huayue Li*, Wenli Li*, Antibiotic angucycline derivatives from the deepsea derived Streptomyces lusitanus. Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1577835

17. Xiao Han#, Lukuan Hou#, Jing Hou, Yongyu Zhang, Huayue Li*, Wenli Li*, Heterologous expression of a vioA variant activates cryptic compounds in a marine-derived Brevibacterium strain. Mar. Drugs 2018, 16, 191

18. Quanquan Liu, Pengfei Ren, Yang Liu, Wen Qin, Huayue Li*, Wenli Li*, Exploration of the glycosyltransferase BmmGT1 from marine-derived Bacillus strain as potential tool enzyme for compound glycol-diversification. J. Microbiol. Biotechnol. 2018, 28, 931-937

19. Tingting Yao, Jing Liu, Zengzhi Liu, Tong Li, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li, Qianqun Gu, Wenli Li* Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery. Nat. Commun. 2018, 9, 4091

20. Huayue Li, Huiming Huang, Lukuan Hou, Jianhua Ju, Wenli Li*, Discovery of antimycin-type depsipeptides from a wbl gene mutant strain of deepsea-derived Streptomyces smaliensis SCSIO ZH66 and their effects on pro-inflammatory cytokine production. Front. Microbiol. 2017, 8:678

1. 2021/01-2024.12，国家自然科学基金面上项目，82073720，基于信号分子激活及“基因组-代谢组-活性”联合策略的深海放线菌中“隐性”抗生素的挖掘，主持

2. 2020/01-2024/12，国家自然科学基金重大项目，81991525，海洋药源分子的定向发掘与异源高效表达，参与（学校子课题负责人）

3. 2020/01-2021/12，中国科学院南海海洋研究所开放实验室课题，LMM2020-3，NMR代谢组分析指导下海洋放线菌中新型抗生素发掘研究，主持

4. 2020/01-2021/12，国家重点研发计划项目“重要深海药源天然产物合成生物学产生体系构建”之课题一，2019YFC0312501，深海药源天然产物生物合成途径解析和调控策略”，参与

5. 2019/12-2024/12，山东省自然科学基金重大项目，ZR2019ZD18，深海微生物代谢产物结构和生物功能研究，参与

6. 2022/01-2024/12，山东省自然科学基金重大项目，ZR2021ZD28, 深海微生物药用活性分子的高效发现与作用机制研究，参与

7. 2016/01-2018/12，国家自然科学基金青年项目，21502180，基于基因组采掘及2D-NMR代谢组分析策略的深海放线菌中新型肽类抗生素的挖掘，主持

8. 2015/06-2017/06，教育部留学回国人员基金项目，教外司留[2015]1098号，基因组信息指导下深海链霉菌中新型非核糖体肽类化合物的发现，主持

9. 2014/12-2017/12，山东省自然科学基金青年项目，ZR2014HQ053，深海链霉菌Streptomyces somaliensis SCSIO ZH66中新型非核糖体肽类化合物的基因组采掘研究，主持