首页 > 分享 > 白蛋白包裹的绿色合成氧化锌纳米花通过细胞内氧化应激抑制皮肤黑色素瘤细胞

白蛋白包裹的绿色合成氧化锌纳米花通过细胞内氧化应激抑制皮肤黑色素瘤细胞

花匠小妙招
2025-01-08 06:40

白蛋白包裹的绿色合成氧化锌纳米花通过细胞内氧化应激抑制皮肤黑色素瘤细胞的生长。

Rong Wang, Lan Zhang, Anam Razzaq, Naveed Ullah Khan, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ali A Shati, Haroon Iqbal, Jiang Ni

摘要

氧化锌（ZnO）在癌症成像和治疗方面具有广阔的应用前景，因此引起了癌症研究的极大兴趣。本研究旨在合成涂有白蛋白的氧化锌纳米花，以积极靶向和抑制皮肤黑色素瘤细胞。我们合成了牛血清白蛋白（BSA）包覆的氧化锌纳米流体（BSA@ZnO NFs），并评估了它对皮肤癌细胞的体外和体内疗效。在植物提取物（Heliotropium indicum）作为封端剂的情况下，通过单步还原法制备了 BSA@ZnO NFs，并通过扫描电子显微镜（SEM）、傅立叶变换红外光谱（FT-IR）和 X 射线衍射（XRD）分析等各种物理化学表征确定了制备的成功。制备的 BSA@ZnO NFs 具有多个锥形翼，呈花朵状，平均水合尺寸为 220.8 ± 12.6 nm。此外，与未包覆 ZnO NFs 相比，BSA@ZnO NFs 通过氧化应激抑制了皮肤癌细胞的生长，从而增强了细胞吸收和杀灭细胞的作用。此外，与 ZnO NFs 相比，BSA@ZnO NFs 在生物安全性、血液循环时间、肿瘤积累和体内肿瘤生长抑制方面均有提高。总之，我们的研究结果表明，BSA@ZnO NFs 有望与化疗一起用于各种癌症的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Albumin-coated green-synthesized zinc oxide nanoflowers inhibit skin melanoma cells growth via intra-cellular oxidative stress.

Zinc oxide (ZnO) has attracted a substantial interest in cancer research owing to their promising utility in cancer imaging and therapy. This study aimed to synthesized ZnO nanoflowers coated with albumin to actively target and the inhibit skin melanoma cells. We synthesized bovine serum albumin (BSA)-coated ZnO nanoflowers (BSA@ZnO NFs) and evaluated it's in vitro and in vivo therapeutic efficacy for skin cancer cells. BSA@ZnO NFs were prepared via single-step reduction method in the presence of plant extract (Heliotropium indicum) act as a capping agent, and further the successful fabrication was established by various physico-chemical characterizations, such as scanning electron microscopy (SEM), Fourier transform infra-red (FT-IR) spectroscopy, and x-rays diffraction (XRD) analysis. The fabricated BSA@ZnO NFs appeared flower like with multiple cone-shaped wings and average hydration size of 220.8 ± 12.6 nm. Further, BSA@ZnO NFs showed enhanced cellular uptake and cytocidal effects against skin cancer cells by inhibiting their growth via oxidative stress compared uncoated ZnO NFs. Moreover, BSA@ZnO NFs showed enhance biosafety, blood circulation time, tumor accumulation and in vivo tumor growth inhibition compared to ZnO NFs. In short, our findings suggesting BSA@ZnO NFs as a promising candidate for various types of cancer treatment along with chemotherapy.

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来源期刊

International Journal of Biological Macromolecules

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.

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