中药及活性成分抗耐药菌作用及其机制研究进展
摘要：
细菌对抗菌药的耐药性可导致感染性疾病治疗难度增加、医疗负担加重及死亡率升高等问题，对全球人类和动物健康造成威胁，目前形势已十分严峻。在减抗禁抗的背景下，开发新的抗菌药或替代品以及抗菌药佐剂已刻不容缓。中药及活性成分在协同抗菌药控制细菌耐药性方面已展示出明显优势，具有广阔的开发应用前景。本文对2017年我国禁止硫酸黏菌素用作促生长剂(中华人民共和国农业部公告第2428号)以来，关于控制耐药菌的中药及活性成分以及其对耐药质粒、外排泵、细胞膜通透性、耐药酶、耐药基因、生物被膜等的作用等的最新研究进展进行综述，以期为开发对耐药菌有效的新抗菌药或抗菌增效剂提供参考。
关键词: 中草药, 中药活性成分, 抗菌药耐药性, 作用机制
Abstract:
Antimicrobial resistance can increase difficult in treatment of infectious diseases, medical burden and mortality, posing a threat to global human and animal health. In the background of reducing and banning antimicrobials, it is urgent to develop new antimicrobials, alternatives, as well as antimicrobials adjuvants. It has been demonstrated that Traditional Chinese medicine and its active components have significant advantages in controlling of antimicrobial resistance in combination with antimicrobials and has broad prospects for development and application. In this study, we reviewed the latest research progress on traditional Chinese medicine and its active components for controlling antimicrobial-resistant bacteria through acting on drug-resistant plasmids, efflux pumps, cell membrane permeability, drug-resistant enzymes, drug-resistant genes and biofilms since 2017 when China banned the use of colistin as a growth promoter (Announcement No. 2428 of the Ministry of Agriculture of China), to provide reference for the development of effective new antimicrobials or their synergist against antimicrobial-resistant bacteria.
Key words: Traditional Chinese Medicine, active ingredients of traditional Chinese medicine, antimicrobial resistance, mechanism
中图分类号:
S853.74
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