725 毛喉鞘蕊花抗癌生物活性成分及其抑制癌细胞增殖的药理药效学研究
725_ XIAO-MING WANG School of Pharmacy, Wuhan University; Key Laboratory of Phytochemistry, Hubei College of Traditional Chinese Medicine, 430065, Wuhan, PR China XIU XING School of Pharmacy, East China University of Science And Technology University shanghai 200237, PR China JIAN-WEN LIU School of Pharmacy, East China University of Science And Technology University shanghai 200237, PR China HE-ZHEN WU Key Laboratory of Phytochemistry, Hubei College of Traditional Chinese Medicine 430065, Wuhan, PR China XIAN-MING HU School of Pharmacy, Wuhan University, 430072, Wuhan, PR China YAN-WEN LIU Key Laboratory of Phytochemistry, Hubei College of Traditional Chinese Medicine 430065, Wuhan, PR China Corresponding author www.taodocs.com 725_ XIAO-MING WANG School of Pharmacy, Wuhan University; Key Laboratory of Phytochemistry, Hubei College of Traditional Chinese Medicine, 430065, Wuhan, PR China XIU XING School of Pharmacy, East China University of Science And Technology University shanghai 200237, PR China JIAN-WEN LIU School of Pharmacy, East China University of Science And Technology University shanghai 200237, PR China HE-ZHEN WU Key Laboratory of Phytochemistry, Hubei College of Traditional Chinese Medicine 430065, Wuhan, PR China XIAN-MING HU School of Pharmacy, Wuhan University, 430072, Wuhan, PR China YAN-WEN LIU Key Laboratory of Phytochemistry, Hubei College of Traditional Chinese Medicine 430065, Wuhan, PR China Corresponding author www.taodocs.com
Coleus forskohlii Briq. (Labiatae) (Coleus Lour.) 。 ， 、 1 、 、 。 ， 、 、 、 ， 。 ， 。 ， ， ， 12 ， :Coleonic Acid ，11-one, 13-methyl, 8(9),13(14)Z-labdadien-15-acid(1),11-ol,13-methyl; Coleolic Acid ，8(9),13(14)Z-labdadien-15-acid(2)，and Colexanthone ，1-oxymethyl-3,5 hydroxyl-7-methyl xanthone(3)，Coleon C(4), ,6,22, ,5α,8α, ,3β, (ergosta-6,22-dien-5α,8α-epidioxy-3β-ol，(5) 14-deoxycoleon U (6), 1l—hydroxysugiol(7) genkwanin(8) 1,6, ,7, ,9, (1α,6β-diacetoxy-8,13-epoxylabd-14-en-11-one，)(9)，，6, (1α,9α-dihydroxy-6β,7α-diacetoxy- 8,13-epoxylabd-14-en-11-one)(10)，，，β, (β-sitosterol，(11)，， (12)， 1、2、3 SciFinder ， 4、5 。 ， ， Coleon C(4)， Coleon C(4) 95D, A375, A431, LOVO, MKN45, BEL-7402,HL60 ， ，Coleon www.taodocs.com Coleus forskohlii Briq. (Labiatae) (Coleus Lour.) 。 ， 、 1 、 、 。 ， 、 、 、 ， 。 ， 。 ， ， ， 12 ， :Coleonic Acid ，11-one, 13-methyl, 8(9),13(14)Z-labdadien-15-acid(1),11-ol,13-methyl; Coleolic Acid ，8(9),13(14)Z-labdadien-15-acid(2)，and Colexanthone ，1-oxymethyl-3,5 hydroxyl-7-methyl xanthone(3)，Coleon C(4), ,6,22, ,5α,8α, ,3β, (ergosta-6,22-dien-5α,8α-epidioxy-3β-ol，(5) 14-deoxycoleon U (6), 1l—hydroxysugiol(7) genkwanin(8) 1,6, ,7, ,9, (1α,6β-diacetoxy-8,13-epoxylabd-14-en-11-one，)(9)，，6, (1α,9α-dihydroxy-6β,7α-diacetoxy- 8,13-epoxylabd-14-en-11-one)(10)，，，β, (β-sitosterol，(11)，， (12)， 1、2、3 SciFinder ， 4、5 。 ， ， Coleon C(4)， Coleon C(4) 95D, A375, A431, LOVO, MKN45, BEL-7402,HL60 ， ，Coleon www.taodocs.com
C(4) 。 。 。 : ; ; Coleon C and other compounds from COLEUS FORSKOHLII BRIQ. inhibited the proliferation of human carcinoma 2 Abstract, In a project to investigate plant derived natural products from the Coleus forskohlii Briq. with anticancer activity, we have identified three new metabolites. The metabolite were assigned as coleonic Acid, 11-one, 13-methyl, 8(9),13(14)Z-labdadien-15-acid(1) ; coleolic Acid,11-ol, 13-methyl, 8(9),13(14)Z-labdadien-15-acid(2) ,and colexanthone,1-oxymethyl-3,5 hydroxyl-7-methyl xanthone(3) by extensive 1- and 2D NMR spectroscopy. The anticancer active principle of this plant was the coleon C(4) which exhibited ED 50values ranging from 1.2–7.0μg/ml against different strains of human cancer cells . Coleon C(4)induced human cancer cells apoptosis and inhibited tumor growth. in vivo Keywords: Coleus forskohlii Briq; anticancer; apoptosis; coleon C 1. Introduction www.taodocs.com C(4) 。 。 。 : ; ; Coleon C and other compounds from COLEUS FORSKOHLII BRIQ. inhibited the proliferation of human carcinoma 2 Abstract, In a project to investigate plant derived natural products from the Coleus forskohlii Briq. with anticancer activity, we have identified three new metabolites. The metabolite were assigned as coleonic Acid, 11-one, 13-methyl, 8(9),13(14)Z-labdadien-15-acid(1) ; coleolic Acid,11-ol, 13-methyl, 8(9),13(14)Z-labdadien-15-acid(2) ,and colexanthone,1-oxymethyl-3,5 hydroxyl-7-methyl xanthone(3) by extensive 1- and 2D NMR spectroscopy. The anticancer active principle of this plant was the coleon C(4) which exhibited ED 50values ranging from 1.2–7.0μg/ml against different strains of human cancer cells . Coleon C(4)induced human cancer cells apoptosis and inhibited tumor growth. in vivo Keywords: Coleus forskohlii Briq; anticancer; apoptosis; coleon C 1. Introduction www.taodocs.com
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