黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察
黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察 投稿时间：2004-04-08 点此下载全文 引用本文：柯晓,周宗梅,文明,文彩云.黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察[J].药学实践杂志,2004,(5):268~270 摘要点击次数: 1399 全文下载次数: 1338中文摘要:目的 探讨黄芪注射液对充血性心力衰竭(CHF)患者的疗效及对免疫调节的影响。方法 对正常体检查者(体检组)和CHF组进行IgA、IgG、IgM、C3、IL-Ⅱ、E-RFC、T-LTT、抗心肌抗体的检查;然后将CHF组患者随机分为两组,治疗组在应用转换酶抑制剂、利尿剂和强心苷等常规治疗的基础上加用黄芪注射液60mL+10%葡萄糖注射液500mL静脉滴注,每日1次,连用2周,对照组仅给予常规治疗;2周后重复上述检查,进行体检组与CHF和治疗组与对照组的对比分析。结果 体检组与CHF组比较,IL-Ⅱ、E-RFC、T-LTT、C3和抗心肌抗体CHF组明显高于体检组(P<0.05);治疗2周后,两组比较心衰治疗的总有效率无明显差异(P>0.05),但显效率治疗组明显优于对照组(P<0.05);治疗组IL-Ⅱ、E-RFC、T-LTT、C3和抗心肌抗体的改变明显优于对照组(P<0.01)。结论 黄芪注射液对心衰的疗效很大程度上是通过对细胞免疫作用实现的,其辅助治疗可获满意的疗效。中文关键词:心力衰竭 充血性 免疫 黄芪注射液 Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation Abstract:Objective To explore the effect of Astragalus membranaceus injection on congestive heart failure and immune regulation. Methods The serum levers of IgA IgG IgM C3 IL-Ⅱ E-RFC T-LTT and antibody of cardiac muscle were measured in normal control group and CHF group. Then the CHF patients were divided randomly into two groups. Treatment group was infused intravenously daily with Astragalus membranaceus injection added into 5% glucose 250mL for two weeks, which was based on conventional therapy such as digitalis, diuretics and vasodilators. Conventional therapy group was only treated with conventional thearpy. Previous measurements were done again after two weeks. Comparative analysis was made between normal control group and CHF group, and also was made between conventional therapy group and treatment group. Results The level of IL-Ⅱ E-RFC T-LTT antibody of cardiac muscle in the CHF paients were significantly higher then that of normal control group (P<0.01). After two weeks, there was no significant difference in the total effective rate of CHF between two groups (P>0.05), but the obvious effective rate of treatment group was markedly higher than that of conventional therapy group(P >0.05). The decrease of IL-Ⅱ E-RFC T-LTT C3 and antibody of cardiac muscle in treatment group is more obvious than that in conventional therapy group (P<0.01). Conclusion The effect of Astragalus membranaceus injection on cogestive heart failure involves mainly the cell immune and Astragalus membranaceus may have a satisfied cure effect on it.keywords:Astragalus membranaceus heart failure congestive immunity 查看全文 查看/发表评论 下载PDF阅读器 关闭 参考文献(共6条):［1］罗海明,戴瑞鸿,李勇,等.黄芪有效成分治疗充血性心力衰竭的心脏病学研究[J].中国中西医结合杂志,1995,15:707.[2]刘星阶,喻振坤.黄芪成分和药理研究进展[J].上海医药,1995,6(2): 23.［3］韦方,王丕荣,李琮辉.慢性充血性心力衰竭患者免疫调节功能的改变及其与脂质过氧化的关系[J].中华心血管病杂志,1999,8(27):315.［4］王振纲,周金黄,主编.中药药理与临床研究进展[M].(第一册)北京:中国科技出版社,1992:254.［5］朱伯卿,戴瑞鸿,龚志铭,等.黄芪注射液对心脏正性肌力作用的研究[J].上海中医药杂志,1987,(1):47.［6］黄兆铨,秦南屏,叶武,等.黄芪对病毒性心肌炎外周血T淋巴细胞亚群的影响[J].中国中西医结合杂志,1995,15(3):28. 相似文献(共20条):[1] 柯晓,周宗梅,文明,文彩云.黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察[J].药学实践杂志,2004,22(5):268-270.[2] 顾旭,尚树忠,郭锐.黄芪注射液辅助治疗充血性心力衰竭68例[J].医药导报,2003,22(8):556-557.[3] 林杰,杨柳.黄芪注射液治疗慢性充血性心力衰竭120例疗效观察[J].中国实用医药,2010,5(31):166-166.[4] 梁建国,王亮,柳涛,何平祥.黄芪配伍丹参注射液治疗慢性心力衰竭39例临床观察[J].中国医药指南,2012(26):254-255.[5] 陈一山.生脉注射液配合治疗充血性心力衰竭60例临床疗效观察[J].福建医药杂志,2006,28(2):41-43.[6] 李玉子.生脉注射液联合镁辅助治疗充血性心力衰竭的疗效观察[J].中国实用医药,2007,2(5):60-61.[7] 李树芳,付长波,吕风莉,刘海霞,徐国卿,殷俊娥,徐静.米力农联合参附注射液治疗充血性心力衰竭的临床研究[J].中国实用医药,2012,7(20):183-184.[8] 张雅红.左卡尼汀对慢性充血性心力衰竭患者血清炎症因子的影响[J].中国药师,2013,16(8):1214-1215.[9] 吕蒙.环磷腺苷葡胺治疗慢性充血性心力衰竭的临床研究[J].实用药物与临床,2013,16(1):39-40.[10] 李玉子.生脉注射液联合镁治疗充血性心力衰竭的疗效观察[J].中国实用医药,2007(5).[11] 董青,吴先旺,张敬芳.黄芪注射液治疗充血性心力衰竭61例疗效观察[J].现代医药卫生,2005,21(3):285-286.[12] 孙明.环磷腺苷葡胺治疗老年慢性充血性心力衰竭的临床观察[J].临床医药实践,2010(8).[13] 张伟,邢峰丽.参麦注射液治疗老年充血性心衰临床观察[J].中国医药指南,2004,2(9):686-688.[14] 赵翠霞.黄芪注射液佐治儿童急性病毒性心肌炎45例[J].中国医药指南,2012,10(9):227-228.[15] 李鸿鸣 王荣华.1,6二磷酸果糖联合黄芪治疗新生儿窒息并心肌损害疗效观察[J].当代医药卫生,2005,2(8):13-14.[16] 何居仁 马丹军.黄芪注射液治疗充血性心力衰竭作用机理探讨[J].上海医药,2000,21(1):25-26.[17] 翟理黄 王梅.黄芪注射液治疗充血性心力衰竭的临床观察[J].上海医药,1995(11):10-12.[18] 王兵,汤红,许顶立.运动训练对充血性心力衰竭患者白细胞的影响[J].实用医药杂志(山东),2003,20(4):251-255.[19] 廖荣宏,李晓丽,王世萍.左旋卡尼汀治疗慢性充血性心力衰竭40例[J].中国药业,2005,14(6):85-86.[20] 许国开.钾镁合剂在慢性充血性心衰治疗中的作用观察[J].福建医药杂志,2000,22(Z1):148-149.
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