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植物化学国家重点实验室“天然产物与创新药物研究”系列讲座（十三）

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2024-11-02 07:45

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Yudai Matsuda博士简历：

Personal data:

Date of Birth: February 6, 1988

Nationality: Japanese

Education:

August 2015, Ph.D., Pharmaceutical Sciences, The University of Tokyo

March 2012, M.Sc., Pharmaceutical Sciences, The University of Tokyo

March 2010, B.Sc., Pharmaceutical Sciences, The University of Tokyo

Professional Experiences:

October 2015-present, Postdoc, Department of Systems Biology, Technical University of Denmark

August 2013-September 2015, Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo

October 2012-July 2013, Project Researcher, Graduate School of Pharmaceutical Sciences, The University of Tokyo

April 2012-September 2012, Researcher, Research & Development Lab., KOHJIN Co., Ltd.

Research Experiences and Interests:

･ Biosynthesis of bioactive and/or complex natural products from fungi

･ Generation of artificial metabolic pathways to afford novel useful small molecules

Representative publications:

(1) Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.* “Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase.” J. Am. Chem. Soc.137, 3393–3401 (2015).

(2) Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.* “Complete biosynthetic pathway of anditomin: Nature’s sophisticated synthetic route to a complex fungal meroterpenoid.” J. Am. Chem. Soc. 136, 15326-15336 (2014).

(3) Matsuda, Y., Awakawa, T., Wakimoto, T., Abe, I.* “Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.” J. Am. Chem. Soc. 135, 10962-10965 (2013).

(4) Matsuda, Y., Mitsuhashi, T., Lee, S., Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M.,* Abe, I.* “Astellifadiene: Structure determination by NMR spectroscopy and crystalline sponge method, and elucidation of its biosynthesis.” Angew. Chem. Int. Ed. 55, 5785-5788 (2016).

(5) Qin, B.,† Matsuda, Y.,† Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I.* “An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping.” Angew. Chem. Int. Ed. 55, 1658-1661 (2016). （†co-first author）

(6) Matsuda, Y., Abe, I.* “Biosynthesis of fungal meroterpenoids.” Nat. Prod. Rep. 33, 26-53 (2016).

(7) Matsuda, Y., Awakawa, T., Mori, T., Abe, I.* “Unusual chemistries in fungal meroterpenoid biosynthesis.” Curr. Opin. Chem. Biol. 31, 1-7 (2016)

(8) Matsuda, Y., Quan, Z., Mitsuhashi, T., Li, C., Abe, I.* “Cytochrome P450 for citreohybridonol synthesis: Oxidative derivatization of andrastin scaffold.” Org. Lett. 18, 296-299 (2016).

(9) Matsuda, Y., Mitsuhashi, T., Quan, Z., Abe, I.* “Molecular basis for stellatic acid biosynthesis: A genome mining approach for discovery of sesterterpene synthases.” Org. Lett. 17, 4644-4647 (2015). （†co-first author）

(10) Matsuda, Y., Awakawa, T., Itoh, T., Wakimoto, T., Kushiro, T., Fujii, I., Ebizuka, Y., Abe, I.* “Terretonin biosynthesis requires methylation as essential step for cyclization.” ChemBioChem 13, 1738-1741 (2012).

(11) Matsuda, Y., Awakawa, T., Abe, I.* “Reconstituted biosynthesis of fungal meroterpenoid andrastin A.” Tetrahedron 69, 8199-8204 (2013).

(12) Matsuda, Y., Abe, I. “Meroterpenoids.” In Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Springer, Chapter 13, pp. 289-301 (2014).