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2024-11-13 05:24

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码上扫一扫！DJ-1抗氧化应激功能研究进展王志勇,汤玲珍,高天文* (第四军医大学西京医院全军皮肤病研究所,西安 710032
*通信作者) 摘要: 氧化应激涉及多种疾病的发生和发展以及人体的衰老过程。DJ-1/PARK7基因编码DJ-1蛋白,研究发现其具有多种生物学功能,包括细胞的恶性转化、雄性精子成熟与受精、促进细胞增殖及抵抗氧化应激等。近年来DJ-1抗氧化应激功能日益受到重视。研究层次包括体外实验、体内实验和临床研究。其机制主要包括自身构型改变、分子伴侣作用、保护线粒体功能、调控抗凋亡基因和抗氧化相关基因。对DJ-1进一步研究可能为氧化应激相关性疾病的预防和治疗提供新策略。关键词: DJ-1/PARK7基因氧化性应激细胞凋亡 DOI：10.3724/SP.J.1008.2012.088 投稿时间：2011-05-18修订日期：2011-06-25 基金项目: Protective effect of DJ-1 against oxidative stress: an advance WANG Zhi-yong,TANG Ling-zhen,GAO Tian-wen* (Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
*Corresponding author.) Abstract: Oxidative stress is implicated in the pathogenesis and progression of various diseases as well as in the natural aging process. DJ-1/PARK7 gene encodes DJ-1 protein, which participates in malignant transformation, sperm maturation and fertilization, cell proliferation promotion, and anti-oxidative stress. The anti-oxidative stress effect of DJ-1 has been drawing increasing attention in recent years. There have been related in vitro, in vivo and clinical studies. The main mechanisms of its anti-oxidation effects included modifying configuration, playing the role of molecular chaperones, protecting the mitochondrial function, and regulating anti-apoptosis genes and antioxidant-related genes. Further research on DJ-1 may provide a new strategy for the prevention and treatment of oxidative stress-related diseases. Key words: DJ-1/PARK7 gene oxidative stress apoptosis 参考文献(共33条):[1] Clements C M;McNally R S;Conti B J;Mak T W Ting J P,DJ1,a cancer-and Parkinson' s disease-associated protein,stabilizes the antioxidant transcriptional master regulator Nrf2,Proceedings of the National Academy of Sciences(USA),2006.[2] Nishinaga H;Takahashi-Niki K;Taira T;Andreadis A IguchiAriga S M Ariga H,Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells,Neuroscience Letters,2005.[3] Mo J S;Jung J;Yoon J H;Hong J A Kim M Y Ann E J,DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1,Journal of Cellular Biochemistry,2010.[4] Lev N;Ickowicz D;Barhum Y;Lev S Melamed E Offen D,DJ-1 protects against dopamine toxicity,Journal of Neural Transmission,2009.[5] Gu L;Cui T;Fan C;Zhao H Zhao C Lu L,Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress,Biochemical and Biophysical Research Communications,2009.[6] van der Brug M P;Blackinton J;Chandran J;Hao L Y Lal A Mazan-Mamczarz K,RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways,Proceedings of the National Academy of Sciences(USA),2008.[7] Meulener M;Whitworth AJ;Armstrong-Cold CE,Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease,Current Biology ,2005, 15(17).[8] Inberg A;Linial M,Protection of pancreatic beta cells from various stress conditions is mediated by DJ-1,Journal of Biological Chemistry,2010.[9] Zhou W;Freed C R,DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity,Journal of Biological Chemistry,2005.[10] ARITINAT C;SHENDELMAN S;JONASON A,Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons:an ES-derived cell model of primary parkinsonism,Plos Biology ,2004, 2(11).[11] Moore DJ ；Zhang L ；Dawson TM ；Dawson VL,A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.,Journal of Neurochemistry ,2003, 87(6).[12] Li HM ；Niki T ；Taira T ；Iguchi Ariga SM ；Ariga H,Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress.,Free radical research ,2005, 39(10).[13] Yang Y;Gehrke S;Haque M E;Imai Y Kosek J Yang L,Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling,Proceedings of the National Academy of Sciences(USA),2005.[14] Chen J;Li L;Chin L S,Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage,Human Molecular Genetics,2010.[15] Canet-Avil s R M;Wilson M A;Miller D W;Ahmad R McLendon C Bandyopadhyay S,The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization,Proceedings of the National Academy of Sciences(USA),2004.[16] Mullett S J;Hamilton R L;Hinkle D A,DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age,Neuropathology:Official Journal of the Japanese Society of Neuropathology,2009.[17] Waragai M;Wei J;Fujita M;Nakai M Ho G J Masliah E,Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease,Biochemical and Biophysical Research Communications,2006.[18] Xu X M;Lin H;Maple J;Bj(o)rkblom B Alves G Larsen J P,The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation,Journal of Cell Science,2010.[19] Yamane K;Kitamura Y;Yanagida T;Takata K Yanagisawa D Taniguchi T,Oxidative neurodegeneration is prevented by UCP0045037,an allosteric modulator for the reduced form of DJ-1,a wild-type of familial Parkinson's disease-linked PARK7,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ,2009, 10.[20] Ishikawa S;Taira T;Niki T;Takahashi-Niki K Maita C Maita H,Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1,Journal of Biological Chemistry,2009.更多... 相似文献(共20条):[1] 王志勇,汤玲珍,高天文.DJ-1抗氧化应激功能研究进展[J].第二军医大学学报,2012,33(1):88-92.[2] 江波赵忠新.睡眠剥夺诱发氧化应激反应研究进展[J].第二军医大学学报,2007,28(2):0201-0203.[3] 余丹,李燕,聂秀.癌基因PARK7/DJ-1在肿瘤中的研究进展[J].医学研究杂志,2016,45(5):6-9.[4] 甘露,袁萱,张红,王振华.Nrf2/Keap1抗氧化系统与缺血性脑病[J].农垦医学,2011,33(1):79-82.[5] 杨鲲.DJ-1蛋白研究进展[J].新乡医学院学报,2010,27(2).[6] 魏旺丽[综述],李萃,詹显全[审校].DJ-1基因的研究进展[J].当代医师,2013(11):1579-1581.[7] 廖永晖,汤雨,千年松,窦科峰.氧化应激与细胞凋亡[J].新乡医学院学报,2011,28(1):110-113.[8] 王婕,贾伟平.心磷脂与氧化应激及胰岛B细胞凋亡[J].上海医学,2008,31(8).[9] 辛颖.线粒体与神经退行性病变[J].医学综述,2008,14(4):520-521.[10] 王强,梁志鹏.肝脏缺血/再灌注损伤与细胞凋亡研究进展[J].医学综述,2009,15(7):990-993.[11] 刘振华,唐北沙,何丹,王磊,肖智权,严新翔,郭纪锋.野生型DJ-1与A39S突变型DJ-1表达的单克隆细胞株基因表达谱分析(英文)[J].湖南医科大学学报,2014(4):325-332.[12] 高想,蒋日磊,蒋凤荣,唐艳芬,姜卫东,张锋莉.利心冲剂对心力衰竭大鼠模型的氧化应激和凋亡相关基因的影响[J].医学研究杂志,2010,39(6):49-52.[13] 周溦,林敬明,王素丽,林海桢.半枝莲总黄酮对延缓秀丽隐杆线虫和人脐静脉内皮细胞衰老的影响[J].南方医科大学学报,2017,37(6).[14] 王配配（摘译）.敲除p21可减轻香烟烟雾、LPS和fMLP引起的小鼠肺部炎症[J].中华医学信息导报,2008,23(15):9-9.[15] 唐茂涵,张艳杰,刘银,等.三甲氧苄嗪对脂肪来源间充质干细胞氧化应激损伤的影响及机制研究[J].四川大学学报(医学版),2017,48(2):173-178.[16] 魏旺丽,汤参娥,詹显全,易红,李萃.siRNA抑制DJ-1基因表达对肺鳞癌SK-MES-1细胞生物学行为的影响[J].中南大学学报(医学版),2013,38(1):7-13.[17] 胡霞,陈方方,孔陈苏.DJ-1对MPP+诱导的多巴胺能神经元损伤的保护机制研究[J].海南医学,2017,28(22).[18] 张晨,李柏,吕书勤,李勇,苏永华,凌昌全.蜂毒素对人肝癌细胞线粒体膜蛋白7A6和凋亡相关基因产物Fas及其配体FasL表达的影响[J].中西医结合学报,2007,5(5):559-563.[19] 张梅英,徐影琪,王惟,赵越,杨葳,于萌,郭晓冲,秦英,郑志红.pcDNA3.1/myc-His-DJ-1M26I重组载体构建及其对NIH3T3细胞增殖和凋亡研究[J].中国比较医学杂志,2012,22(1):28-33.[20] 张梅英,任萍萍,徐影琪,王惟,赵越,杨葳,于萌,郭晓冲,秦英,郑志红.DJ-1L166P与DJ-1M26I基因对NIH3T3细胞增殖和凋亡的比较[J].中国比较医学杂志,2012,22(4):10-14.