外耳道真菌病致病曲霉菌菌种鉴定及药物敏感性检测
Journal of Audiology and Speech Pathology（2023）
长江大学附属荆州医院
Abstract
目的 鉴定外耳道真菌病的致病曲霉菌种,并检测它们对常用抗真菌药物的敏感性.方法 收集2020年10月至2021年5月诊断为外耳道真菌病的94例患者,外耳道分离真菌检测均为曲霉菌,采集患者外耳道排出物,行真菌涂片荧光染色镜检,同时行真菌培养,对培养后的菌落提取真菌DNA行ITS区扩增并测序分析.选取4种常用的抗真菌药联苯咔唑(PCB)、克霉唑(CLO)、特比萘芬(TRB)和伊曲康唑(ITR)行抗真菌药物敏感性检测.结果 94例患者外耳道真菌病患者中共分离获得5种曲霉菌,其中土曲霉菌48株(51.1％),黄曲霉菌25株(26.6％),黑曲霉菌13株(13.8％),烟曲霉菌7株(7.4％),花斑菌霉菌1株(1.1％).药敏结果显示,22株黄曲霉菌对PCB耐药(MIC＞16 μg/ml),耐药率88.0％;7株对CLO耐药(MIC＞16 μg/ml),耐药率28.0％.黑曲霉菌4株对PCB耐药(MIC＞16 μg/ml),耐药率30.8％;5株对CLO耐药(MIC＞16μg/ml),耐药率38.5％.烟曲霉菌2株对PCB耐药(MIC＞16 μg/ml),耐药率28.6％;2株对CLO耐药(MIC＞16 μg/ml),耐药率28.6％.土曲霉菌4株对PCB耐药(MIC＞16μg/ml),耐药率8.3％;17株对CLO耐药(MIC＞16 μg/ml),耐药率35.4％.所有曲霉菌仅有1株黑曲霉菌对ITR耐药(MIC＞8 μg/ml),1株土霉菌对TRB耐药(MIC＞8 μg/ml).结论 土曲霉菌是本组外耳道真菌病患者分离出的最常见的曲霉菌菌种.曲霉菌对PCB和CLO耐药率相对偏高,而对TRB和ITR耐药率极低,故治疗外耳道真菌病时应首选TRB或ITR.
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Key words
Otomycosis,Aspergillus,Drug sensitivity test
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Pretraining has recently greatly promoted the development of natural language processing (NLP)We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performanceWe propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generationThe model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in ChineseExperimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performanceUpload PDF to Generate Summary
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