线粒体靶向抗氧化剂研究进展
全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050 葛越 延安市宝塔区妇幼保健院, 陕西 延安 716000 蒋炜 兰州军区兰州总医院药剂科, 甘肃 兰州 730050
全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050 景临林 兰州军区兰州总医院药剂科, 甘肃 兰州 730050
全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050 马慧萍 兰州军区兰州总医院药剂科, 甘肃 兰州 730050
全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050 贾正平 兰州军区兰州总医院药剂科, 甘肃 兰州 730050
全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050 pharmapaper@hotmail.com 基金项目:国家自然科学基金资助项目(81202458);全军医药卫生科研项目(CLZ12JB06)中文摘要:线粒体是细胞呼吸的主要场所,在细胞的生命周期中扮演重要角色,三羧酸循环和氧化磷酸化都是在线粒体中进行。线粒体功能障碍可导致一系列疾病,如缺血-再灌注损伤、败血症和糖尿病等。线粒体是神经退行性病变的治疗靶点,也是药物转运策略研究的引人注目的靶位。虽然线粒体所介导的疾病进程的分子机制尚未完全阐明,但氧化应激是关键的环节。开发线粒体靶向的抗氧化应激保护药物具有诱人的前景。线粒体靶向抗氧化剂是指以线粒体为作用靶位的具有抗氧化作用的药物。该文介绍了现有的线粒体靶向抗氧化剂的概念、分类及其疾病治疗研究进展。中文关键词:线粒体靶向 抗氧化剂 活性氧 氧化应激 Research progress in mitochondria-targeted antioxidants Abstract:Mitochondria are the main places of cellular respiration as well as the citric acid cycle and oxidative phosphorylation.It plays an important role in controlling the life and death of cells.Mitochondrial dysfunction leads to a series of human diseases such as ischemia-reperfusion injury,sepsis and diabetes.Mitochondrial become an attractive target for drug transporters strategy and therapeutic targets for neurodegeneration.Although the molecular mechanisms responsible for mitochondria mediated disease processes are not fully elucidated yet,the oxidative stress appears to be critical.Accordingly,strategies are being developed for the targeted delivery of antioxidants to mitochondria.The prospect of development of mitochondrial targeted drugs with anti-oxidative stress protection is tempting.Mitochondrial targeting antioxidants were the antioxidant drugs which took mitochondria as the target site.In this review,weintroduced the conception and classification of mitochondrial targeted antioxidants and the research progress of disease treatment by mitochondrial targeted antioxidants.keywords:mitochondria-targeted antioxidant reactive oxygen species oxidative stress 查看全文 查看/发表评论 下载PDF阅读器 关闭 参考文献(共33条):[1] Jordan J,de Groot PW,Galindo MF.Mitochondria:the headquarters in ischemia-induced neuronal death[J].Cent Nerv Syst Agents Med Chem,2011,11:98-106.[2] Finkel T.Radical medicine:treating ageing to cure disease[J].Nat Rev Mol Cell Biol,2005,6:971-976.[3] Fantinelli JC,Perez Nunez IA,Gonzalez Arbelaez LF,et al.Participation of 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